Clayton Custer's short jumper with 3.6 seconds lifted Loyola-Chicago to a 63-62 upset Saturday over Tennessee.
Tennessee's Jordan Bone had a chance to win it for the third-seeded Vols, but his last-second shot bounced out.
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The 11th-seeded Ramblers advance to the Sweet 16 in Atlanta, where they will take on the winner of Sunday's game between No.2-seeded Cincinnati and No. 7 Nevada.
No. 3 Michigan 64, No. 6 Houston 63
Michigan needed Jordan Poole's 3-pointer at the buzzer to propel the Wolverines to the Sweet 16 Saturday night.
Poole's shot as time ran out lifted Michigan to a 64-63 win over Houston in the second round. The Cougars trailed late but came back to take a 63-61 lead on the strength of free throws by Devin Davis. However, Davis missed three of his final four at the line giving Michigan the opportunity to win it at the buzzer.
The Cougars were led by Rob Gray Jr. with 23 points and 10 rebounds. The Wolverines had four players in double figures.
Michigan will meet the winner of Sunday's matchup between No. 7 Texas A&M and No. 2 North Carolina. That Sweet 16 game will be played Thursday in Los Angeles.
No. 3 Texas Tech 69, No. 6 Florida 66
The Texas Tech Red Raiders will make their first appearance in the Sweet 16 since 2005 by defeating Florida 69-66 Saturday night. The Gators missed a couple 3-point attempts that would have tied the game in the final seconds.
Tech's four-guard attack was led by Keenan Evans with 22 points, Zhaire Smith added 18 points and 9 rebounds, while Jarrett Culver finished with 11 points and 9 rebounds.
Florida also finished with three players in double figures; Jalen Hudson led the way with 23, Egor Koulechov with 12 and Chris Chiozza added 11.
The Red Raiders will face either No. 2 Purdue or No. 10 Butler Thursday in Boston.
No. 4 Gonzaga 90, No. 5 Ohio State 84
The three-point shooting of freshman Zach Norvell Jr. staked Gonzaga to an early lead over Ohio State and the Zags held off a late surge by the Buckeyes to advance to the Sweet 16 for the fourth straight season.
Ohio State was led by Keita Bates-Diop's 28 points, and Kam Williams added 19 for Ohio State, who trailed by 11 at the half.
Gonzaga will face the winner of Sunday's game between the West Region's top seed, Xavier, and 9th-seeded Florida State.
No. 1 Kansas 83, No. 8 Seton Hall 79
Kansas, the No. 1 seed in the Midwest Region, is headed to the Sweet 16 for the third consecutive year after the Jayhawks held off Seton Hall 83-79 in Wichita on Saturday.
The Jayhawks were led by Malik Newman's 28 points. Seton Hall's Angel Delgado had 24 points and 23 rebounds, and Khadeen Carrington finished with 28 points, including a string of 3-pointers late that kept the game within reach for the 8th-seeded Pirates.
Kansas will face the winner of Sunday's game between 4th-seeded Auburn and 5th-seed Clemson in Omaha.
No. 5 Kentucky 95, No. 3 Buffalo 75
After upsetting Arizona in a 21-point first-round blowout, 13th-seeded Buffalo managed to keep it close against Kentucky most of the way Saturday. But led by 27 points from Shai Gilgeous-Alexander, the Wildcats pulled away in the fourth quarter to defeat the Bulls 95-75 to advance to the Sweet 16.
Gilgeous-Alexander also contributed 6 rebounds and 6 assists, while Hamidou Diallo had 22 points and 8 rebounds. Wes Clark had 26 points for Buffalo.
Kentucky will play the winner of No. 5 seed Kansas State and Maryland-Baltimore County, which became the first 16 seed in NCAA history to knock off a top seed when it stunned Virginia on Friday night.
No. 2 Duke 87, No. 7 Rhode Island 62
Freshman Marvin Bagley III had 22 points and nine rebounds as Duke rolled over Rhode Island 87-62 on Saturday to advance to the Sweet 16.
Duke put the game out of reach early. The 2nd-seeded Blue Devils shot 57 percent from the field, including 10 of 21 from three-point range. Guard E.C. Matthews led No. 7 seed Rhode Island with 23 points.
Duke will play the winner of Sunday's game between No. 3 Michigan State and No. 11 Syracuse.
No. 1 Villanova 81, No. 9 Alabama 58
The No. 1 seed VIllanova Wildcats knocked out ninth-seeded Alabama Crimson Tide in a 81-58 second-round win as the NCAA Men's Tournament continued Saturday.
After scoring only a point in the first half, Villanova junior Mikal Bridges started the second half by scoring 19 of his 23 points in under five minutes.
Villanova (31-5), which won it all in 2016, lost as either a 1 or 2 in 2010, 2014, 2015 and 2017.
Now in the Sweet Sixteen, Villanova is set to take on the the winner of No. 13 seed Marshall-No. 5 seed West Virginia.
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