Spring is the time of optimism in the NFL with most teams hopeful that the moves made this offseason will lead to success in the fall.

The NFL’s new year officially kicked off Wednesday, two days after teams began spending big money in free agency.

The opening of free agency for the San Francisco 49ers was more about their losses than their additions.

Brock Purdy hurt his surgically repaired throwing elbow late in a loss to the Detroit Lions, the latest blow in an injury-plagued season for the San Francisco 49ers.

The San Francisco 49ers have suspended linebacker De’Vondre Campbell for the final three games of the regular season after he refused to enter a game after losing his starting job.

San Francisco coach Kyle Shanahan said linebacker De’Vondre Campbell won’t be part of the 49ers moving forward after he refused to enter a game after losing his starting job.

San Francisco linebacker De’Vondre Campbell refused to enter the game in the third quarter after losing his starting job when Dre Greenlaw returned from an injury.

Joshua Karty kicked four field goals and the Los Angeles Rams survived a slugfest a week after winning a shootout, beating the San Francisco 49ers 12-6 in a key game in the NFC West race.

San Francisco 49ers linebacker Dre Greenlaw went down with a freak injury when he tore his Achilles tendon in the first half of the Super Bowl against Kansas City.

Christian McCaffrey scored his second touchdown on a 6-yard run with 1:07 to play, and the San Francisco 49ers mounted their first second-half comeback of the season to beat the Green Bay Packers 24-21 in a divisional-round playoff game.

The NFL has denied the Eagles’ appeal of a $100,000 fine and the league’s ban of the team’s security chief, Dom DiSandro, from the sideline for the remainder of the regular season.

Two people familiar with the league’s decision told The Associated Press the NFL has banned Eagles security chief Dom DiSandro from being on the sideline for the remainder of the regular season after he was ejected from a game for a scuffle with 49ers linebacker Dre Greenlaw.

The Eagles security chief who was ejected in last week’s game for his role in a scuffle with 49ers linebacker Dre Greenlaw has been barred by the NFL from the sideline for Sunday night’s game against the Cowboys.

Brock Purdy threw for 314 yards and four touchdowns, Deebo Samuel scored three TDs and Eagles quarterback Jalen Hurts was checked for a concussion in the San Francisco 49ers’ 42-19 win over Philadelphia.

San Francisco 49ers linebacker Dre Greenlaw was ejected from Sunday’s 42-19 win against Philadelphia for putting his hand in the face of the Eagles’ chief security officer.

The San Francisco 49ers are built to win with intelligence and toughness.

The Miami Dolphins quarterback at the center of the NFL's overhaul of its concussion protocols and the Ukrainian city that's home to Europe's largest nuclear plant are among this year's list of most mispronounced words.

San Francisco forced two fumbles from Alvin Kamara to become the first team in nearly 21 years to hold New Orleans scoreless and the 49ers beat the Saints 13-0 for their fourth straight win.

Christian McCaffrey ran for the go-ahead touchdown with 7:54 to play, and the San Francisco 49ers beat the Los Angeles Chargers 22-16 in their first game back from a bye week.

Christian McCaffrey became the 11th player in NFL history with a rushing touchdown, a passing touchdown and a receiving touchdown in one game, and the San Francisco 49ers extended their regular-season mastery over the Rams to four full years with a 31-14 victory over Los Angeles.

San Francisco 49ers playmaker Deebo Samuel will miss Sunday’s key NFC West showdown against the rival Los Angeles Rams with an injured hamstring.

Patrick Mahomes threw for 424 yards and three touchdowns to rally Kansas City back from another double-digit deficit in the Chiefs’ 44-23 victory over the San Francisco 49ers.

Dre Greenlaw returned an interception for a touchdown to help the San Francisco 49ers score 17 points over two-plus minutes late in the first half and they held on for a 41-33 win over the Detroit Lions.

Garoppolo threw three TD passes in the first half and Jason Verrett’s first interception in more than four years helped preserve the lead, giving the 49ers a 24-16 victory over the Los Angeles Rams on Sunday night. This week got us back on track.”San Francisco’s defense stepped up with some key stops in the second half. Verrett's interception was part of a rough day overall for Jared Goff, who also missed an open Kupp on a deep ball earlier in the second half. Garoppolo found Kittle on a one-on-one matchup with Darious Williams on a fourth-and-2 play that turned into a 44-yard TD. INJURY REPORT49ers: RB Raheem Mostert (ankle) S Jaquiski Tartt (groin) and C Ben Garland (calf) all left in the second half and didn't return.

Jeudy is active for the Bucs game as Denver quarterback Jeff Driskel makes his first start while Drew Lock recovers from a shoulder injury. Cardinals: QB Brett Hundley, WR Christian Kirk, RB Eno Benjamin, OL Mason Cole, OL Josh Miles, DL Leki Fotu. ___CHICAGO AT ATLANTABears: CB Duke Shelley, OG Arlington Hambright, NT Daniel McCullers, WR RIley Ridley, OLB Trevis GipsonFalcons: WR Julio Jones, CB A.J. Browns: WR Donovan Peoples-Jones, CB Greedy Williams, LB Jacob Phillips, Olivier Vernon, Evan Brown and WR Rashard Higgins. Brown, CB Chris Jackson OLB Derick Roberson, C Aaron Brewer, TE Geoff Swaim, DT Matt DickersonVikings: WR Tajaé Sharpe, WR K.J.