Chase Cunningham passed for 408 yards and three touchdown and Middle Tennessee State stunned No. 25 Miami 45-31 for its first win in 21 tries against ranked opponents.
Mario Cristobal was a winner in his Miami opener.
The Atlantic Coast Conference has four new coaches for this season, all in the same division.
Miami welcomed new coach Mario Cristobal with an introductory news conference in Coral Gables, Florida.
Miami quarterback D’Eriq King needs surgery to repair his right shoulder and will miss the remainder of the season.
Miami quarterback D’Eriq King has a shoulder injury that will need further evaluation this week in the latest blow to the reeling Hurricanes.