Brock Purdy threw three touchdown passes in his return from a toe injury, Christian McCaffrey had two rushing touchdowns and a receiving score, and the San Francisco 49ers beat the sloppy Arizona Cardinals 41-22.

Ahkello Witherspoon made a diving interception on a deflected pass in the end zone with 37 seconds to play, and the Los Angeles Rams barely maintained command of the NFC West race with a 13-9 victory over the Arizona Cardinals on Saturday night.

The Texans got two of the best players in the NFL draft in the first three picks.

Will Shipley scored twice and freshman quarterback Cade Klubnik rallied No. 5 Clemson to a pair of fourth-quarter touchdowns in a 27-21 victory over No. 14 Syracuse.

Clemson quarterback Trevor Lawrence (16) throws a pass during an NCAA college football game against Syracuse in Clemson, S.C., on Saturday, Oct. 24, 2020. 1 Clemson used a late boost to pull away to a 47-21 victory after Syracuse drew within a score at 27-21. Syracuse (1-5, 1-4), a 45-point underdog, rallied from 17-0 down to draw within a touchdown late in the third quarter before Clemson regained its footing. The Syracuse Orange couldn't finish this one off, however. There seemed no way Syracuse should be in position to scare the Tigers, yet it had its chances late.