Gary Sanchez homered and drove in four runs, Ramón Laureano scored four times and the Baltimore Orioles stormed back from an early six-run deficit to rout the Tampa Bay Rays 22-8.

Brandon Lowe hit a tying two-run homer in the fifth inning and the Tampa Bay Rays overcame an eight-run deficit to beat the Baltimore Orioles 12-8 on Wednesday night in the largest comeback in the majors this season.

There is a Lowe family reunion this weekend in Texas.

The mother of Tampa Bay Rays outfielder Josh Lowe and Texas Rangers first baseman Nathaniel Lowe will not make the trip to Tropicana Field for this week’s AL Wild Card Series featuring her sons because she is battling cancer and undergoing chemotherapy.

Manuel Margot flared a run-scoring single to right field to complete a two-run ninth and the playoff-bound Tampa Bay Rays beat the Los Angeles Angels 5-4.

Luke Raley doubled and later scored on Isaac Parades’ infield grounder at the start of an eight-run eighth inning for Tampa Bay, and the Rays rallied from a 4-0 deficit to beat the Seattle Mariners 15-4.

Isaac Paredes homered and drove in four runs as the MLB-best Tampa Bay Rays took two of three from the NL West-leading Los Angeles Dodgers with an 11-10 victory.

Taylor Walls hit a tiebreaking grand slam in the fifth inning, Jose Siri caught Aaron Judge’s fly in front of the center-field wall for the final out and the Tampa Bay Rays beat the New York Yankees 8-7 for a four-game series split.

The Tampa Bay Rays ran their season-opening win streak to 11 games, using another homer for Brandon Lowe and a strong performance by Shane McClanahan to beat the Boston Red Sox 7-2.

The Baltimore Orioles’ winning streak ended at 10 when Christian Bethancourt hit his first home run for Tampa Bay and the Rays rallied for a 5-4 victory.

Gerrit Cole took a no-hit bid into the eighth inning, Aaron Hicks hit a tiebreaking triple in the ninth as Manuel Margot slammed into the right-field wall and the New York Yankees beat the Tampa Bay Rays 4-2 for their 50th win.

Yankees pitcher Gerrit Cole has no-hit the Tampa Bay Rays through seven innings, and New York leads 2-0.

Cubs veteran Kyle Hendricks is set to deliver the first pitch of the season against Corbin Burnes and Milwaukee at Wrigley Field just past 2:20 p.m. EDT, the first of seven games still on the calendar amid rainy forecasts across the country.