Tommy DeVito replaced an injured Drew Lock late in the first quarter and led New York on two first-half scoring drives that Eric Gray capped with runs of 48 and 1 yard as the Giants beat the Detroit Lions 14-3 in a preseason opener limited to mostly backups.

Christian McCaffrey scored a touchdown in his 12th straight game, Brock Purdy threw two TD passes and the San Francisco 49ers won their 13th straight regular season game, 30-12 over the New York Giants.

Tom Brady became the NFL’s all-time completions leader and threw his 700th touchdown pass for the winning score as the defending Super Bowl champion Tampa Bay Buccaneers got a 33-27 overtime victory over the Buffalo Bills on Sunday.

Josh Allen passed for 260 yards and four touchdowns, Buffalo’s defense stifled New Orleans’ short-handed offense and the Bills rolled to a 31-6 victory that sent the injury-ravaged Saints to their fourth straight loss.

Undrafted rookie Salvon Ahmed and veteran Matt Breida combined for 208 yards rushing Sunday to lead the Dolphins to a 22-12 victory over the Patriots, who were eliminated from postseason contention. This is a big win.”Breida added 86 yards and the Dolphins totaled a season-high 250, the most allowed by New England in seven years. The Patriots (6-8) will finish at .500 or worse for the first time since 2000, the year they drafted Tom Brady. They were shut out in the first half, but mounted a 14-play, 90-yard touchdown drive midway through the second half to take the lead for good. DE John Simon (hamstring) and C David Andrews (calf) were sidelined in the second half.

(AP Photo/Aaron Doster)Dallas running back Ezekiel Elliott is inactive against San Francisco with a calf injury the two-time rushing championship has been battling for several weeks. Safety Deon Bush (foot) is also out after being listed questionable with Johnson. Cowboys: RB Ezekiel Elliott, QB Ben DiNucci, WR Malik Turner, CB Rashard Robinson, DE Bradlee Anae, LB Luke Gifford, DE Ron’Dell Carter. ___JACKSONVILLE AT BALTIMOREJaguars: CB Sidney Jones, CB Luq Barcoo, LB Quincy Williams, DT Daniel Ross, QB Jake Luton. Ravens: DE Calais Campbell, CB Jimmy Smith, CB Marcus Peters, RB Mark Ingram, LB Kristian Welch, DE Jihad Ward, C Trystan Colon-Castillo.

(AP Photo/Charles Rex Arbogast)The Latest on the effects of the coronavirus outbreak on sports around the world:___Detroit Lions defensive end Everson Griffen was placed on the COVID-19 list a day before he was expected to play a key role against Green Bay. The Lions announced Griffen is on the list created for players who either test positive for the coronavirus or have been in close contact with an infected person. Detroit elevated defensive end Kareem Martin and offensive tackle Dan Skipper from the practice squad Saturday. The Lions acquired Griffen from Dallas in October and he has 2 1/2 sacks and three passes defended in five games. Running backs Matt Breida (COVID-19 list) and Salvon Ahmed (shoulder) were already sidelined.

Miami Dolphins quarterback Tua Tagovailoa (1) celebrates his first NFL play with Miami Dolphins running back Matt Breida (22), Miami Dolphins guard Ted Karras (67) and Miami Dolphins running back Lynn Bowden (15) against the New York Jets during an NFL football game, Sunday, Oct. 18, 2020, in Miami Gardens, Fla. Tagovailoas winning personality helped the Miami Dolphins avoid locker room backlash when he was promoted to replace popular veteran Ryan Fitzpatrick. (AP Photo/Doug Murray)MIAMI – Tua Tagovailoa’s winning personality helped the Miami Dolphins avoid any locker room backlash when he was promoted to replace popular veteran Ryan Fitzpatrick. Even so, players who have spoken publicly regarding the change say they're excited about Tagovailoa becoming the starter. Under Tagovailoa, the Dolphins hope their offense will be even more dynamic. “Just like everybody else, I'm excited to see him in his first start.”___More AP NFL: https://apnews.com/NFL and https://twitter.com/AP_NFL___Follow Steven Wine on Twitter: http://twitter.com/Steve_Wine

San Francisco 49ers postseason breakout star Raheem Mostert requested a trade from the team after being unable to renegotiate his contract. Agent Brett Tessler made the request public on Wednesday after talks with the 49ers failed to lead to a new deal to replace the three-year contract Mostert signed in 2019 when he was still mostly a special teams standout. After months of unproductive talks with the 49ers about fairly adjusting Raheem Mosterts contract (which paid him for special teams) we have requested a trade, Tessler wrote on Twitter. The 49ers already traded running back Matt Breida to Miami earlier this offseason, leaving Mostert, Coleman, Jerick McKinnon and Jeff Wilson as the veteran halfbacks on the roster. He led the 49ers in rushing with 772 yards and ranked second in the NFL to Ravens quarterback Lamar Jackson by averaging 5.64 yards per carry.

Von Miller’s 95-game starting streak is over because of an injured left knee. The Denver Broncos star edge rusher hurt his left knee at Buffalo last week and is inactive against the Los Angeles Chargers. He wore a cap and shorts as he tested out the knee on the field a few hours before kickoff. Ravens: QB Trace McSorley, WR Jaleel Scott, S Bennett Jackson, CB Anthony Averett, CB Iman Marshall, G Ben Powers, DT Zach Sieler. Jaguars: LB Myles Jack, S Ronnie Harrison, QB Joshua Dobbs, CB Tae Hayes, OL Brandon Thomas, TE Seth DeValve, DT Dontavius Russell.